DETOX
When toxins build up over time, they can contribute to chronic inflammation, oxidative stress, and cellular damage, which are underlying factors in the development of various chronic diseases. Detoxification plays a crucial role in the prevention of such diseases by minimizing the accumulation of toxins and reducing their potential harmful effects on the body.
Results of this panel are presented by toxin types:
Car fumes, Secondary tobacco smoke, Petrochemicals, Pesticides, Textured house paint, Fabrics (furniture), PCBs, (insulating fluids), Phthalates (plastic), VOCs, Chemical solvents, Heavy metals (lead, mercury, cadmium)
Meats cooked at high temperatures (charred, grilled, deep fried) ; Coffee; Alcohol
Statins, Paracetamol, Metamizole
(Analgin)
Emotional toxins (negative attitude, negative emotions, anger, envy, fear), serotonin system; dopamine system, oxidized lipoproteins, ammonia, gastrointestinal detox, protection of microbiome, B12 absorption, evacuation of lipoproteins / cognitive brain fog, B9 metabolism, bilirubin, homocysteine, metabolic waste of hormones (oestrogens).
Cosmetics, deodorants, shampoos, hair dyes, household products; parabens.
The DETOX panel investigates genetic predispositions of both detoxification phases:
PHASE I
- Hydroxylation renders toxins water – soluble and occurs with the involvement of more than 100 enzymes from the cytochrome P450 group.
- Conjugation combines toxins with another substance, either with other toxins, enzymes, or amino acids.
Genes: CYP1A1, CYP1A2, CYP1B1, C YP2C9, CYP3A4, PON1, MAOA
PHASE II
- Sulphation, which involves the conjugation of toxins with sulphate.
- Conjugation with glutathione. Glutathione is a major antioxidant in our body, and through its conjugation, heavy metals, pesticides, and the most dangerous carcinogens are eliminated from the body.
- Glucuronidation – the most energy – demanding process of detoxification, as it processes a large amount of toxins. It detoxifies drugs, steroid hormones, preservatives, nicotine, and bilirubin. Genetic defects in this phase can lead to Gilbert’s syndrome.
- Acetylation , which neutralizes histamine, serotonin, exhaust gases, tobacco, and other substances.
- Methylation – that occurs in four cycles that form the basis of methylation: Urea cycle, Ammonia cycle, Folate cycle, Methionine cycle.
Genes: COMT, GSTM1, GSTP1, NAT2, SULT1A1, SULT1E1, SULT2A1, UGT1A1, MAOB, CBS
Secondary detox involvement genes: APOE, MTHFR, FUT2