WOMAN’S HEALTH

Genetic variations play a key role in programming individual’s susceptibility to emotional and mental stressors. One critical factor is the regulation of neurotransmitters, such as serotonin, dopamine, and norepinephrine, which are involved in mood regulation. Genetic variations can impact the production, breakdown, or receptor sensitivity of these neurotransmitters, leading to differences in an individual’s emotional responses, motivation, energy levels and stress resilience.

Genes:COMT, MAOA, MAOB, ESR1, ESR2, CYP17A1,DRD1,DRD2, ADRB1, ADRB2, NQO1, SRD5A2.

Hormonal predispositions are the aging blueprint for a woman’s body–from skin quality, fertility, and energy to premature aging–all revolves around hormones. It is extremely important to understand genetic predispositions that are responsible for hormonal synthesis and secretion, including estrogen, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and others, as they are essential for overall hormonal balance. These genes can affect the sensitivity and responsiveness of hormone receptors, influencing how effectively hormones exert their effects throughout the body.

Genes: CYP1B1, COMT, MTHFR, GSTM1, GSTP1, SULT1A1, SULT1E1, SULT2A1, CYP19A1, CYP3A4.

Genes control the production and activity of enzymes involved in detoxification processes of phase I and phase II metabolic pathways. Variations in genes encoding these enzymes can affect their efficiency, resulting in differences in an individual’s ability to metabolize and eliminate toxins. Genetic factors can influence the functioning of liver enzymes, including cytochrome P450 enzymes, glutathione S-transferases, and N-acetyltransferases, which are crucial for detoxification. A well-functioning detoxification system is essential forprotection against chronic diseases and premature aging.

Genes: UGT1A1, UGT1A6, SULT1A1, SULT2A1, SULT1E1, MAOB, ABCB1.

Genetic predispositions program the enzymes involved in homocysteine metabolism, such as methylenetetrahydr ofolate reductase. It is essential in the breakdown and recycling of homocysteine. If the function of these enzymes is impaired, it can lead to reduced efficiency in homocysteine metabolism, which can lead to a higher risk of cardiovascular disease and stroke.

Genes : GSTP1, GSTM1, UGT1A1.

Bone health and bone aging is largely programmed by genetic predispositions, as they play a key role in production and regulation of proteins involved in bone formation, the rate of bone turnover, mineralization, and overall bone mass. They also program the absorption, utilization, and metabolism of nutrients essential for bone health, such as calcium and vitamin D.

Genes: GSTP1, GSTM1, UGT1A1.